Treatment of Neonatal Tetanus with High Dosage Diazepam

Neonatal tetanus treated with high dosage diazepam.

The combination of continuous intravenous infusion of diazepam (20--40 mg/kg per day) and intragastric phenobarbitone (10--15 mg/kg per day in 4 divided doses) was used to treat 19 cases of neonatal tetanus. Mortality was 2/19 (11%). This regimen was considered to have reduced the mortality and the need for artificial ventilation. The main side effects encountered were severe drowsiness, coma, ...

Assisted respiration in the treatment of neonatal tetanus.

Conservative management of severe tetanus neonatorum is attended by a very high mortality (Tompkins, 1958; Wright, 1960a; Adams, Holloway, and Thambiran, 1964). Tracheostomy in addition to sedation has not been successful in preventing respiratory failure, which necessitated mechanical ventilation (IPPV) in about 90% of the patients described by Holloway (1967). Although IPPV has been shown to ...

Intrathecal anti-tetanus human immunoglobulin in the treatment of neonatal tetanus.

OBJECTIVE To determine the outcome of tetanus in neonates treated with intrathecal tetanus immunoglobulin in terms of mortality and hospital stay. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Paediatric Unit I, Bahawal Victoria Hospital, Bahawalpur, from April 2004 to December 2007. METHODOLOGY Seventy neonates with diagnosis of neonatal tetanus were included in the study....

Eliminating Neonatal Tetanus

Neonatal tetanus associated with skin infection.

A 1-week-old infant was brought to a regional hospital with a history of recurrent seizures following lower abdominal septic skin infection. She was found to have neonatal tetanus, and a spatula test was positive. The tetanus infection was associated with a superficial skin infection, common in neonates. Treatment included sedatives (diazepam, chlorpromazine, phenobarbitone and morphine), muscl...